Synergistic effect of CTLA-4 blockade and cancer chemotherapy in the…

Synergistic effect of CTLA-4 blockade and cancer chemotherapy in the…

Several chemotherapeutics exert immunomodulatory effects. One of these is the nucleoside analogue gemcitabine, which is widely used in patients with lung cancer, ovarian cancer, breast cancer, mesothelioma and several other types of cancer, but with limited efficacy.