Correspondence: Dr Y Sekido, Division of Molecular Oncology, Aichi Cancer Center Research Institute, Kanokoden 1-1, Chikusa-ku, Nagoya, Aichi 464-8681, Japan. E-mail: ysekido@aichi-cc.jp Malignant mesothelioma is one of the most aggressive neoplasms usually associated with asbestos exposure and is highly refractory to current therapeutic modalities.